DOSING

DOSING INFO

Desidustat - Dosing Information#

  Starting dose Maximum dose limit Dosage adjustment
Nondialysis 100 mg orally thrice in a week [Dosing 2 days apart but not 4 days apart] 150 mg According to the patient’s haemoglobin (Hb) level every 4 weeks (Table 1)
Dialysis Erythropoiesis-stimulating Agent (ESA)-naïve patients:
100 mg orally thrice in a week [Dosing 2 days apart but not 4 days apart]
ESA-experienced patients:
100 mg or 125 mg or 150 mg thrice in a week [Dosing 2 days apart but not 4 days apart]		 150 mg ESA-experienced patients based on previous Epoetin/ Darbepoetin/Methoxy polyethylene glycol-epoetin beta dose (Table 2)
  • Desidustat dosing to be continued until Hb target attainment of 12 g is achieved
  • In dialysis patient, Desidustat is recommended to be taken after completion of the dialysis session

Desidustat - Dose Adjustments Rules#

Change in Hb g% level every 4 weeks Hb <10 g% Hb 10 to <11 g% Hb 11 to <12 g% Hb ≥12 g%
<1.0 increase Increase the dose Increase the dose Maintain the dose Stop the treatment for 14 days, initiate one lower dose if Hb <11.5 g%
≥1.0 increase to
≤2.0 increase		 Maintain the dose Maintain the dose Decrease the dose
>2.0 increase Maintain the dose Decrease the dose Decrease the dose
  • Change in Hb g% level was monitored every 2 weeks (first 8 weeks)
  • 25 mg increase/decrease in the dose as per Hb level every 4 weeks

Desidustat - Starting Doses of Desidustat in Patients Converting from Epoetin/Darbepoetin/Methoxy Polyethylene Glycol-Epoetin Beta#

Epoetin (IU/week) Darbepoetin (µg/week) Methoxy polyethylene glycol-epoetin beta (µg/month) Desidustat (mg, three times in a week)
<8000 <40 <120 <100
8000 to 16000 40-80 120-200 125
>16000 >80 >200 >150

Overdosage#

No incidence of overdose with Desidustat has been reported. In case of overdose with Desidustat, healthcare professional (HCP) to be consulted if symptoms deteriorate. General supportive care of the patient is indicated, including monitoring of vital signs and observation of clinical status.

Missed dose#

When a patient misses a dose of Desidustat, next scheduled dose will be administered to the subjects. However, missed dose will not be administered to the subject.

REFERENCES:

#Desidustat package insert dated 21st Feb 2022.